← Index·Pyridine coenzyme·V.
NAD+.
Nicotinamide adenine dinucleotide — a coenzyme central to oxidation-reduction reactions in every living cell. Identified by Harden and Young, 1906; structural characterization completed by Warburg, 1936.
Your body already makes NAD+ in every cell, and uses it in the redox reactions that produce most of your energy. Whether supplementation raises functional cellular levels is exactly what the last decade of research is trying to answer.
The longevity-adjacent term the internet loves. Two decades of receptor biology don't fit in a wellness caption. The literature is where the sirtuin substrate chemistry actually lives.
Straight talk
Straight talk: NAD+ is well-characterized biochemistry. Whether exogenous NAD+ (or its precursors NR/NMN) reaches cellular pools in humans at a magnitude that matters is contested in the literature — bioavailability, tissue partitioning, and dose-response are all open questions.
What the research studies
The literature, not a summary of it.
The modern NAD-longevity literature centers on David Sinclair (Harvard), Shin-ichiro Imai (Washington University), and Charles Brenner (UNC). Journals: Cell Metab, Nature, Sci Adv, Cell Reports. Inspect the corpus yourself:
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